产品名称：FKHR
- 产品型号：兔单抗 IgG
- 产 地：美国
- 制 造 商：epitomics公司
- 产品规格：100ul
- 产品报价：$235美元 元(人民币) / PCS
- 关 注 度：946 次 [产品手册下载]
- 供 应 商：杭州华安生物技术有限公司
- 公司位于：浙江省 杭州市
- 备注:本信息仅针对企事业单位，不对个人用户适用
产品介绍
详细介绍：
Clone ID: EP927Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1874-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 80 kDa
UniProt ID: Q12778
Description: FKHR （FoxO1）, a member of the FoxO subfamily of forkhead transcription factors, is an important target for insulin and growth factor signaling in the regulation of metabolism, cell cycle and proliferation, and survival in peripheral tissues （1）. FKHR is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion. It has been shown that FoxO1 is induced in the early stages of adipocyte differentiation but that its activation is delayed until the end of the clonal expansion phase. Constitutively active FoxO1 prevents the differentiation of preadipocytes, while dominant-negative Foxo1 restores adipocyte differentiation of fibroblasts from insulin receptor-deficient mice （2）. Conserved residue （Ser329） is a novel in-vivo phosphorylation site on FKHR. Phosphorylation of this site also decreases the ability of FKHR to stimulate gene transactivation and reduces the proportion of FKHR present in the nucleus （3）
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| Name: FKHR Rabbit Antibody PDF of Datasheet |
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Clone ID: EP927Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1874-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 80 kDa
UniProt ID: Q12778
Description: FKHR （FoxO1）, a member of the FoxO subfamily of forkhead transcription factors, is an important target for insulin and growth factor signaling in the regulation of metabolism, cell cycle and proliferation, and survival in peripheral tissues （1）. FKHR is regulated by insulin via Akt-dependent phosphorylation and nuclear exclusion. It has been shown that FoxO1 is induced in the early stages of adipocyte differentiation but that its activation is delayed until the end of the clonal expansion phase. Constitutively active FoxO1 prevents the differentiation of preadipocytes, while dominant-negative Foxo1 restores adipocyte differentiation of fibroblasts from insulin receptor-deficient mice （2）. Conserved residue （Ser329） is a novel in-vivo phosphorylation site on FKHR. Phosphorylation of this site also decreases the ability of FKHR to stimulate gene transactivation and reduces the proportion of FKHR present in the nucleus （3）
Specificity: A synthetic peptide corresponding to residues surrounding Ser329 of human FKHR was used as immunogen. Anti-FKHR RabMab recognizes both phosphorylated and unphosphorylated FKHR.
Recommended Dilutions:
WB: 1:1000
IHC: 1:250 – 500
ICC: 1:100 - 250
Protocols for using Epitomics Rabbit Monoclonal Antibodies
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| A. Western blot analysis on NIH/3T3 cell lysate using anti-FKHR RabMAb （cat. #1874-1）, dilution 1:1000 | B. Immunohistochemical staining of paraffin-embedded human bladder carcinoma using anti-FKHR RabMAb （cat. #1874-1）. |
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| C. Immunofluorescent staining of HeLa cells using anti-FKHR RabMAb （cat. #1874-1）. |
References:
| 1. | Gan L, et al. J. Neurochem 93（5）:1209-19, 2005 |
| 2. | Nakae J, et al. Dev Cell 4（1）:119-29, 2003 |
| 3. | Woods YL, Biochem J. 355（3）:597-607, 2001 |
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产品图片
![FKHR[兔单抗 IgG]](/viewpic.htm?url=uploadfile/Image/2007-7/1618221617338.jpg)
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