产品名称：GAP43 （C-term）
- 产品型号：兔单抗 IgG
- 产 地：美国
- 制 造 商：epitomics公司
- 产品规格：100ul
- 产品报价：$235美元 元(人民币) / PCS
- 关 注 度：496 次 [产品手册下载]
- 供 应 商：杭州华安生物技术有限公司
- 公司位于：浙江省 杭州市
- 备注:本信息仅针对企事业单位，不对个人用户适用
产品介绍
详细介绍：
Clone ID: Polyclonal
Antibody Type: Rabbit Polyclonal IgG Affinity Purified
Catalog#: 1751-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC, FC, IP
Species Reactivity: Human, Rat
Mol. Weight: 48 kDa
UniProt ID: P17677
Description: Growth associated protein GAP43 （B-50, F1, neuromodulin） is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C （PKC）, phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system （1）. Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation （LTP） （2）. These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons （3）. During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 （4）.
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| Name: GAP43 （C-term） Rabbit Antibody PDF of Datasheet |
  |
Clone ID: Polyclonal
Antibody Type: Rabbit Polyclonal IgG Affinity Purified
Catalog#: 1751-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC, FC, IP
Species Reactivity: Human, Rat
Mol. Weight: 48 kDa
UniProt ID: P17677
Description: Growth associated protein GAP43 （B-50, F1, neuromodulin） is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C （PKC）, phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system （1）. Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation （LTP） （2）. These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons （3）. During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 （4）.
Specificity: A synthetic peptide corresponding to residues in the C-term of human GAP-43 was used as an immunogen.
Recommended Dilutions:
WB: 1:10,000
IHC: 1:250 – 500
ICC: 1:250 – 500
Flow Cytometry: 1:50
IP: 1:50
Protocols for using Epitomics Rabbit Monoclonal Antibodies
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| A. Western blot analysis using anti-GAP43 Rabbit Polyclonal on SH-SY-5Y cells lysate. （cat. # 1751-1）, dilution 1:10,000. | B. Immunohistochemical analysis of paraffin-embedded human astrocytoma using anti-GAP-43 Rab pAb.jpg Rab pAb （cat. # 1751-1）. |
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| C. Immunofluorescent staining of PC-12 cells using anti-GAP43 Rab pAb （cat. # 1751-1）. |
References:
| 1. | McIntosh H. et al. Visual Neuroscience. 2: 583-591, 1989. |
| 2. | Gianotti C, et al. Neuron 8:843-8, 1992. |
| 3. | Skene JH, et al. Science 233:783-786, 1986. |
| 4. | Neve RL, et al. J Neuro 18:7757-7767, 1998. |
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产品图片
![GAP43 （C-term）[兔单抗 IgG]](/viewpic.htm?url=uploadfile/Image/2007-7/152031589498.jpg)
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