产品名称：IL-17

详细介绍：

Name: IL-17 Antibody PDF of Datasheet

Clone ID: EP434Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1656-1
Size: 100ul
Price: $ 210

Recommended Applications: WB
Species Reactivity: Human, Mouse

Mol. Weight: 32 kDa
UniProt ID: Q16552

Description: Interleukin 17 （IL-17） is a pro-inflammatory cytokine produced by TCRα/β+ CD4 CD8 thymocytes, as well as by activated CD4+ and CD4+ CD45RO+ memory T cells （1）. IL-17 stimulates the expression of TNFalpha, IL-1 beta, IL-6, and IL-8 （2）. In addition, IL-17 is involved in the induction of inducible nitric oxide synthase and cyclooxygenase 2 in chondrocytes （3）. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis （4）.

Specificity: A recombinant human IL-17 was used an immunogen.

Recommended Dilutions:
WB: 1:1,000-5,000 （approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane）

Protocols for using Epitomics Rabbit Monoclonal Antibodies

A. Western blot analysis using anti-IL-17 RabMAb （cat. # 1656-1）, dilution 1:5,000. （approximately 0.05ug/lane [0.5ug/200ul] of recombinant protein was loaded on the membrane）

References:

1.	Yao, Z. , Painter, S. L. , Fanslow, W. C. , Ulrich, D. , Macduff, B. M. , Spriggs, M. K. & Armitage, R. J. （1995） J. Immunol. 155, 5483-5486
2.	Fossiez, F. , Banchereau, J. , Murray, R. , Van Kooten, C. , Garrone, P. & Lebecque, S. （1998） Int. Rev. Immunol. 16, 541-551
3.	Shalom-Barak, T. , Quach, J. & Lotz, M. （1998） J. Biol. Chem. 273, 27467-27473
4.	Ziolkowska, M. , Koc, A. , Luszczykiewicz, G. , Ksiezopolska-Pietrzak, K. , Klimczak, E. , Chwalinska-Sadowska, H. & Maslinski, W. （2000） J. Immunol. 164, 2832-2838

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