产品名称：M-CSF
- 产品型号：兔单抗 IgG
- 产 地：美国
- 制 造 商：epitomics公司
- 产品规格：100ul
- 产品报价：$235美元 元(人民币) / PCS
- 关 注 度：380 次 [产品手册下载]
- 供 应 商：杭州华安生物技术有限公司
- 公司位于：浙江省 杭州市
- 备注:本信息仅针对企事业单位，不对个人用户适用
产品介绍
详细介绍：
Clone ID: EP1179Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1876-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC, IP
Species Reactivity: Human
Mol. Weight: 19/37 kDa
UniProt ID: P09603
Description: Colony stimulating factor-1 （M-CSF） is a glycoprotein growth factor required for the proliferation and differentiation of mononuclear phagocytic cells. Findings indicate that M-CSF, under hormonal influence, plays a role in placental development and function and that steroid hormones may regulate developmental processes via their effects on the expression of tissue-specific growth factors （1）. M-CSF accelerates neointimal formation after vascular injury via the SDF-1-CXCR4 system, and the inhibition of this system has therapeutic potential for the treatment of cardiovascular diseases （2）. The immunosuppressor Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability （3）. Several studies have demonstrated that CSFs are closely associated with tumor progression, metastasis and invasion through autocrine or paracrine mechanism in lung cancer （4）.
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| Name: M-CSF Rabbit Antibody PDF of Datasheet |
  |
Clone ID: EP1179Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 1876-1
Size: 100ul
Price: $ 235
Recommended Applications: WB, IHC, ICC, IP
Species Reactivity: Human
Mol. Weight: 19/37 kDa
UniProt ID: P09603
Description: Colony stimulating factor-1 （M-CSF） is a glycoprotein growth factor required for the proliferation and differentiation of mononuclear phagocytic cells. Findings indicate that M-CSF, under hormonal influence, plays a role in placental development and function and that steroid hormones may regulate developmental processes via their effects on the expression of tissue-specific growth factors （1）. M-CSF accelerates neointimal formation after vascular injury via the SDF-1-CXCR4 system, and the inhibition of this system has therapeutic potential for the treatment of cardiovascular diseases （2）. The immunosuppressor Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability （3）. Several studies have demonstrated that CSFs are closely associated with tumor progression, metastasis and invasion through autocrine or paracrine mechanism in lung cancer （4）.
Specificity: A synthetic peptide corresponding to residues on human M-CSF was used as an immunogen.
Recommended Dilutions:
WB: 1:50,000 （5 ng recombinant protein）
IHC: 1:50 – 100
ICC: 1:250 – 500
IP: 1:50
Protocols for using Epitomics Rabbit Monoclonal Antibodies
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| A. Western blot analysis on 5 ng of recombinant protein using anti-M-CSF RabMAb （cat. # 1876-1）, dilution 1:50,000. | B. Immunohistochemical staining of paraffin-embedded human tonsils using anti-M-CSF RabMAb （cat. #1876-1）. |
References:
| 1. | Pollard JW, et al. Nature 330（6147）:484-6, 1987. |
| 2. | Shiba Y, et al. Arterioscler Throm Vasc Biol, 27（2）:283- 9,006 |
| 3. | Sanchez-Tillo E, et al. Eur J Immunol. 36（9）:2515-24, 2006 |
| 4. | Uemura Y, et al. Int J Mol Med 18（2）:365-73, 2006. |
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产品图片
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